英俊帅气、年轻有为的泰德•格雷（Milo Ventimiglia 米洛•文堤米利亚 饰）事业爱情双得意，他以优异的成绩从哈佛医学院毕业，随后被推荐进入全国最有名的病理学研究小组；另一方面，泰德和女友格雯（Alyssa Milano 阿莱萨•米兰诺 饰）感情顺利，令人欣羡。凭借出众的才干与丰富的学识，泰德很快便在这人才辈出的研究小组中崭露头角，受到同侪的赏识与器重。但他很快便发现，这个小组的工作人员似乎隐藏着不为人知的秘密。原来，这些衣冠楚楚研究人员竟然暗中进行一连串的杀人事件，他们为了创造出完美的杀人纪录而疯狂竞赛。泰德同时发现，自己也在其中越陷越深。是逃脱，还是同流合污，他面临着痛苦而危险的选择……
凯亨（法利·格兰杰）恨自己不守妇道的妻子，意图谋害；布鲁罗（罗伯特·沃特）想杀死自己的父亲。一次他们在火车上偶遇，两人互诉衷肠，协议互换杀人。布鲁罗轻松的杀掉了凯亨的妻子，凯亨却难以下手。布鲁罗以嫁祸凯亨相要挟，转瞬间凯亨从杀人走向了为自己洗脱罪责而奔命。 火车上的怪客，改变了凯亨的命运，也让他卷进了危险的漩涡。
"The Perfect Murder" brings viewers some of the most diabolical, perplexing murder cases to land on detectives’ desks – the kind of cases that make or break careers and provide fodder for Hollywood mystery movies. These ingenious killers are every detective’s worst nightmare. Whether by planting false evidence, or writing anonymous letters to police, these murderers will stop at nothing to stay one step ahead and get away with the perfect murder. Detectives hit dead end after dead end, and wrong suspects are discarded. But one new clue can lead to another and the cold case suddenly gets hot. The truth is that it is the perfect murder -- until it's not.
For ten years, Julia Bickleigh has despised and bullied her husband. For ten years Dr Bickleigh has dreamed of romance ... and escape.
