A quiet woman receives a social media request from a middle-school friend, who she doesn’t remember fondly. The two meet at a hotel’s restaurant where they find a room numbered 666 containing Rokuroku, a long-neck woman wearing a red kimono.
Teppei and Kamiya, two average joes working in the electronic services industry, stumble upon the intergalactic bounty-hunter Ilia, and her partner, the artificial intelligence named Bob. Both men are accidentally transported to the Zone, a virtual reality in which Bob has trapped Ilia's latest prey, a biological weapon named Zeram. The Earth natives must both survive the experience and help Ilia capture Zeram before the Zone disappears around them.
Intergalactic bounty hunters Iria and Bob return to track down an ancient mystical relic. When a second Zeiram unit shows up and goes berserk, it takes all of Iria's resources to survive a deadly game of cat-and-mouse with the fearsome space creature.
In a futuristic version of medieval Japan, a band of swordsmen battles an evil warlord and his mechanical army of ninjas, and are aided by a mysterious heroic cyborg ninja, Shiranui.
A monster hunter goes after a beast that could be her brother.
A retired warrior comes to see his former lord and learns that someone is making indestructible swords from some unknown metal. He is sent together with a swordsman to investigate the source. Along the way they meet a young girl working as a beekeeper. She is later witness to the appearance of three strange females from another dimension. They are searching for a lost weapon that has landed on earth and as one of them lay dying she enlists the girl to help them control the strange beast/weapon. Meanwhile the warrior and the swordsman learn that an old nemesis has created the swords from the shell that surrounded the alien weapon. Soon the alien beast/weapon is awakened and battle for control ensues.
Behind the scenes of Zeiram 2
