I fortsettelsen på eventyret til demon-superhelten Hellboy, bryter en ond alv en gammel pakt mellom mennesker og skapninger, da han erklærer krig mot menneskeheten. Han er på en misjon for å frigjøre The Golden Army, en dødelig gruppe kampmaskiner som kan ødelegge menneskeheten. Da helvete på jord er klar til å bryte ut, setter Hellboy og hans mannskap ut for å beseire den onde prinsen.
In the near future after a bitter civil war leaves Manhattan a demilitarized zone (DMZ), destroyed and isolated from the rest of the world, fierce medic Alma Ortega sets out on a harrowing journey to find the son she lost in the evacuation of New York City at the onset of the conflict. Standing in her way are gangs, militias, demagogues and warlords, including Parco Delgado, the popular — and deadly — leader of one of the most powerful gangs in the DMZ.
Journalist Kayama Seiji who is covering the war zone, gets shocking news that Shinozuka Yoshio, the criminal serving time for the murder of a young girl 12 years ago, is actually innocent. At that time, Kayama reported on that case. Convinced that Shinozuka was the criminal, Kayama had proceeded to write the news stories, but he is proved to be wrong after the passage of 12 years. Shinozuka's lawyer, Ishihara Yoko, holds a press conference where she criticises the sloppy investigation by the police and speaks of suing for the suffering during the 12 years that Shinozuka had lost. However, Shinozuka's daughter, Miho has mixed feelings for her father who is released from prison at this late stage.
