A Chinese Department of Health junior clerk Su Zhenghuai is with his eldest daughter Su Wei and son Su Yuexuan are on their way to visit relatives in the provincial city when they meet the long-lost second daughter Su Ling. Unfortunately, the train is attacked by rats. Su Yuexuan is bitten by a rat and goes into a coma. In order to save his young son and many bitten passengers, Su Zhenghuai and Su Wei decide to make the dangerous venture to Xiaobaihe Hospital to get medicine.
The evil Black Dragon Jie Hook feeds on emotions such as bitterness, fear and sorrow. He creates a plague on earth and sends the demon dragon Fish Bu Confusion (Roy Cheng) and the tree demon Pu Kwai (Zhang Chuxuan) to capture his nemesis Li Xin Yuan (Chen Haomin) in his dreams. In the course of the assassination, Pu Kui is impressed by Li Xin Yuan's kindness and integrity in saving the people and gradually swayed. The assassination mission is delayed again and again, and the suffering on earth makes the evil dragon accumulate enough strength to come to earth to kill his destined enemy Li Xin Yuan himself.
